白大昌

      白大昌 博士，副教授，硕士生导师

        本科毕业于郑州大学化学系，博士毕业于中国科学院上海有机化学研究所，获2020年“Thieme Chemistry Journal Award”国际学术期刊奖，获河南省第十五届青年科技奖，并获“河南省优秀青年科技专家称号”，2020年 河南省优秀青年基金，邮箱地址：baidachang@126.com; baidachang@htu.edu.cn

教育经历：

2005.09 - 2009.07: 郑州大学，化学专业，理学学士

2009.09 - 2014.07: 中国科学院上海有机化学研究所，有机化学专业，理学博士（硕博连读），导师：侯雪龙 研究员

工作经历：

2014.07 - 2015.08: 中科院上海有机所金属有机国家重点实验室，助理研究员

2015.10–2016.10: 美国内布拉斯加医学研究中心，博士后

2016.11-2020.04：3499cc拉斯维加斯，讲师

2020.04-至今：3499cc拉斯维加斯，副教授

研究兴趣和领域：

1，发展以绿色合成化学为导向的新反应方法和技术，研究过渡金属催化碳碳键活化以及手性氟化合物的合成新方法。

2，研究具有潜在生物活性分子的合成。

近年来主持的主要科研项目:

1， 国家自然科学基金-青年项目，铜催化肟酯与缺电子烯烃的环加成反应，2019-2021， 26万

2.    河南省优秀青年科学基金，过渡金属催化不对称C-C/C-O 键活化反应研，2020-2023，25万元

代表性论文：

(27). Wu, Hao.; Wang, Yiyao.; Sui, Shiyuan.; Chen, Gongming.; Wang, Lei.; Yang, Jiaxin.; Chang, Junbiao.;* Bai, Dachang*Enantioselective Desymmetrization and Parallel Kinetic Resolution of Cyclopropanes via C–C Activation: Synthesis of Chiral β-Lactams.Chem, 2024, 10.1016/j.chempr.2024.08.005.

(26). Bai, Dachang.;* Zhong, Kangbao.; Chang, Lingna.; Qiao, Yan.; Wu, Fen.; Xu, Guiqing.; Chang, Junbiao.* Nickel-catalyzed regiodivergent hydrosilylation of α-(fluoroalkyl)styrenes without defluorination.Nat. Commun. 2024, 15, 6360.

(25). Bai, Dachang.;* Guo, Xiuli.; Wang, Xinghua.; Xu, Wenjie.; Cheng, Ruoshi. Wei, Donghui.; Lan, Yu.; Chang, Junbiao.* Umpolung reactivity of strained C–C σ-bonds without transition-metal catalysis. Nat. Commun. 2024, 15, 2833.

(24).Bai, Dachang.*; Wu, Fen.; Chang, Lingna.;Wang, Manman.; Wu, Hao.; Chang, Junbiao.* Highly Regio- and Enantioselective Hydrosilylation of gem-Difluoroalkenes by Nickel Catalysis. Angew. Chem. Int. Ed.  2022, 61, e202114918.  (Highlight by Synfacts 2022, 18, 0398)

(23). Bai, Dachang.*; Yu, Yanjiang.; Guo, Haiming.; Chang, Junbiao.; Li, Xingwei.* Nickel(0)-Catalyzed Enantioselective [3+2] Annulation of Cyclopropenones and a,b-Unsaturated Ketones/Imines. Angew. Chem. Int. Ed.  2020, 59, 2740-2744. (Highlight by Synfacts 2020.16.641)

(22). Bai, Dachang.; Wang, Xueli.; Zheng, Guangfan.; Li, Xingwei.* Redox-Divergent Synthesis of Fluoroalkylated Pyridines and 2-Pyridones through Cu-Catalyzed N-O Cleavage of Oxime Acetates. Angew. Chem. Int. Ed. 2018, 57, 6633-6637. 

(21) Wu, Fen.; Chang, Junbiao.; Bai Dachang*. Synthesis of Sterically Hindered Dialkyl Ethers via Palladium-Catalyzed Fluoro-alkoxylation of gem-Difluoroalkenes.Org. Lett.2024, 26, 4953−4957.

(20). Wu, Fen.; Li, Xin.; Chang, Junbiao.; Bai, Dachang.* Palladium-catalyzed multi components oxy-aminofluorination and aminofluorination of gem-difluoroalkenes. Chin Chem Lett.2024, 35, 109155.

(19). Bai, Dachang.;* Li, Xin.; Wu. Fen.; Chang, Junbiao.* Stereoselective hydrodefluorination of CF3-substituted alkenes and gem-difluoroalkenes by H⁻.Org. Chem. Front.,2024,11, 1388–1394.

(18). Wu, Hao.; Liu, Zhen.; Bai, Dachang.*¹H NMR Spectrum of Amide Compounds.Univ. Chem. 2024, 39, 231.

(17). Bai, Da-Chang.*; Guo, Yuanyuan.; Ma, Dandan.; Guo, Xiuli.; Wu, Hao. Copper-Catalyzed Hydroamination of gem-Difluoroalkenes Access to Diversified α‑Difluoromethyl Amines. Org. Lett. 2023, 25, 533-537.

(16).Chen, Junyan.; Bai, Dachang.;^* Guo, Xiuli.; Wang, Yiyao.;Li, Xingwei.* Diastereodivergent [4+2] Annulation of Biphenylenes with Enones via Nickel(0)-catalyzed C-C bond Activation. Chin Chem Lett. 2022. 33, 5056-5060.

(15). Bai, Dachang.;*  Liu, Song.; Chen, Junyan.; Yu, Yanjiang.; Wang, Manman.; Chang, Junbiao.; Lan., Yu.;* Li, Xingwei.* Mechanistic studies on nickel-catalyzed enantioselective [3 + 2] annulation for γ-butenolide synthesis via C–C activation of diarylcyclopropenones.Org. Chem. Front., 2021, 8, 3023-3031.

(14). Bai, Dachang.;* Chen, Junyan.; Zheng, Bingbing.;  Li, Xueyan.; Chang, Junbiao*. Catalytic [3+3] Annulation of β-Ketoethers and Cyclopropenones via C(sp3)-O/C-C Bond Cleavage under Transition-Metal Free Conditions. Chin. J. Chem. 2021, 39, 2769-2773.

(13). Cui, Yixin.; Bai, Dachang.;* Liu,Bingxian.;Chang, Junbiao.;*Li, Xingwei.* Rh(III)-Catalyzed Acylation of Heteroarenes with Cyclobutenones via C–H/C–C Bond Activation. Chem. Commun., 2020, 56, 15631-15634.

(12). Xu, Guiqing.; Chen, Qi.; Wu, Fen.; Bai, Dachang.;* Chang, Junbiao.;* Li, Xingwei.* Rh(III)-Catalyzed Chemodivergent Coupling of N‑Phenoxyacetamides and Alkylidenecyclopropanes via C−H Activation.Org. Lett. 2021, 23, 2927−2932.

(11). Cheng, Ruoshi.; Bai, Dachang.* Enantiodivergent Relay Coupling for Nickel-Catalyzed Stereoselective Functionalization of Cyclopropylzinc Reagents.Chin. J. Org. Chem. 2021, 41, 1746-1748.

(10). Cui, Yixin.; Bai, Dachang.;* Liu,Bingxian.;Chang, Junbiao.;*Li, Xingwei.* Rh(III)-Catalyzed Acylation of Heteroarenes with Cyclobutenones via C–H/C–C Bond Activation. Chem. Commun., 2020, 56, 15631-15634.

(9). Li, Xue-yan.; Yu, Yanjiang.; Qi, Ruobing.; Bai, Dachang*. Facile access to fluoroalkylated 2-aminopyridines by Cu-catalyzed [3 + 3] couplings of oxime esters with β-CF3 acrylonitrile. Tetrahedron Lett. 2020. 61, 151858-151861. 

(8). Dai, Hongxue.; Wu, Fen.; Bai, Dachang*. Recent Advances in Ni-Catalyzed C-C bond Activation Reactions. Chin. J. Org. Chem. 2020. 40. 1423-1436.

(7). Bai, Dachang. ^(#); Xia, Jintao. ^(#); Song, Fangfang .; Li, Xueyan.; Liu, Bingxian.; Liu, Lihong.; Zheng, Guangfan.; Yang, Xifa.; Sun, Jiaqiong, * Li, Xingwei.* Rhodium(III)-catalyzed diverse [4 + 1] annulation of arenes with 1,3-enynes via sp³/sp² C–H activation and 1,4-rhodium migration. Chem. Sci. 2019, 10. 3987-3993. (#: co-first authors)

(6) Yang Siqi, Li Xin, Peng Zhuojin, Yu Wenyan, Wang Guangxu, Jin Yalan, Zheng Bingbing, Dai Hongxue, Bai Dachang.* Synthesis of Pentafluoroethylated Pyridines via Cu-Catalyzed[3+3] Cycloaddition Reaction of Oxime Acetates. Chin. J. Org. Chem., 2019, 39, 1623-1629.

(5).Bai, Dachang.*;Xu, Teng.; Ma, Chaorui.; Zheng, Xin.; Liu, Bingxian.; Xie, Fang.; Li, Xingwei.* Rh(III)-Catalyzed Mild Coupling of Nitrones and Azomethine Imines with Alkylidenecyclopropanes via C−H Activation: Facile Access to Bridged Cycles.  ACS Catal. 2018, 8, 4194-4200.  

(4). Yu, Feile.^(#); Bai, Dachang.^(#) ; Liu, Xiuyan.^(#); Jiang, Yangjie.; Ding, Changhua.*; Hou, Xue-Long.* Pd-Catalyzed Allylic Alkylation of gem-Alkyl, Aryl-Disubstituted Allyl Reagents with Ketones: Diastereoselective Construction of Vicinal Tertiary and Quaternary Carbon Centers. ACS Catal. 2018, 8, 3317–3321.(#: co-first authors)

(3) Bai. Dachang.; Jia, Qingqian.; Xu, Teng.; Zhang, Qiuqiu.; Wu, Fen.; Ma, Chaorui.; Liu, Bingxian.; Chang, Junbiao.; * Li, Xingwei.* Rhodium(III)-Catalyzed C–H Activation of Nitrones and Annulative Coupling with Nitroalkenes. J. Org. Chem. 2017, 82, 9877–9884.

(2) Bai. Dachang.; Liu, Xiu-Yan.; Li, Hao.; Ding, Changhua.;* Hou. Xue-Long.* Tandem Thorpe Reaction/Palladium Catalyzed Asymmetric Allylic Alkylation: Access to Chiral β-enaminonitriles with Excellent Enantioselectivity.Chem. Asian J. 2017, 12, 212–215.

(1) Bai, Dachang.; Yu, Feile.; Wang, Wanying.; Chen, Di.; Li, Hao.; Liu, Qingrong.; Ding, Changhua.; Chen, Bo.*; Hou, Xue-Long.* Palladium/N-heterocyclic carbene catalysed region and diastereoselective reaction of ketones with allyl reagents via inner-sphere mechanism. Nat. Commun.  2016, 7, 11806–11817.