详细介绍


陈豪华,男,博士,副研究员,硕导

邮箱:chenhaohua@htu.edu.cn

地址:3499cc拉斯维加斯实训楼606




教育经历:

2013.9-2017.6  海南师范大学       理学学士

2017.9-2023.6  重庆大学(硕博连读)  理学博士   导师:蓝宇教授


工作经历:

2023.7-至今 3499cc拉斯维加斯


研究领域与兴趣:

1.均相催化反应的机理及选择性研究;

2.机制导向的核苷药物分子构筑;

3.分子动力学模拟。


近年来主持的主要科研项目:

1.国家自然科学基金-青年项目,2025-2027,主持

2.河南省科技攻关项目,2024-2026,主持

3.3499cc拉斯维加斯博士科研启动项目, 2024-2027,主持


代表性论文:

(1) Chen, L.; Chen, H.*; Xu, L.; Cao, K.; Yang, M.; Liu, Y.; Liu, S.; Lan, Y.*; Zhang, Z.*; Zhang, G. “Photooxidative tandem cyclization of enamines to polysubstituted pyrroles: a combined experimental and theoretical study”. Green Chem.202527, 1423.

(2) Wang, Y.; Li, Y.; Chen, H.*; Lan, Y.; Pi, C.; Wu, Y.; Cui, X.* Enantioselective de novo construction of 3‑oxindoles via organocatalyzed formal [3 + 2] annulation from simple arylamines”. Nat. Commun. 202415, 6183.

(3) Xie, H.; Chen, H.*; Dutta, U.; Lan, Y.; Breit, B*. “Photochemical Asymmetric Palladium-Catalyzed Allylation Reaction: Expeditious Entry to Chiral 1,2-Amino Alcohols and 1,2-Diamines”. ACS Catal. 202414, 13352.

(4) Chen, H.; Dang, Z.; Sha, X.; Wang, Y.; Zhang, Z.; Luo, Y.*; Lan, Y.* “Variable Mechanisms for Cobalt-Catalyzed Alkyne Dimerization Pinpointed by Quasi-Classical Trajectory Simulations”. ACS Catal. 2024 14, 16469.

(5) Li, W.#;Chen, H.#; Zheng, Y.; Lu, Y.; Xie, J.; Chen, S.; Lan, Y.*; Song, Q.Copper- and Palladium-Cocatalyzed Chemo-, Regio-, Stereo-, and Atroposelective Arylboration of 1,3-Enynes”. ACS Catal. 202414, 11318.

(6) Zhou, W.#; Xi, S.#Chen, H.#; Jiang, D.; Yang, J.; Liu, S.; He, L.; Qiu, H.; Lan, Y.*; Zhang, M.* “A Bridged Backbone Strategy Enables Collective Syntheses of Strychnan Alkaloids”. Nat. Chem202315, 1074. 

(7) Chen, H.Li, Y.*; Liu, S.; Xiong, Q.; Bai, R.; Wei, D.*; Lan, Y.* “On the mechanism of homogeneous Pt-catalysis: A theoretical view”. Coor. Chem. Rev. 2021437, 213863.

(8) Xi, S.#; Dong, J.#Chen, H.#Dong, Q.; Yang, J.; Tan, Q.; Zhang, C.; Lan, Y.*; Zhang, M.* “Lewis acid–catalyzed domino generation/[2,3]-sigmatropic rearrangement of ammonium ylidesto access chiral azabicycles”. Sci. Adv. 2021, 7, eabd5290. 

(9) Xiong, Y.#; Du, Z.#Chen, H.#; Yang, Z.; Tan, Q.; Zhang, C.; Zhu, L.; Lan, Y.*; Zhang, M.* “Well-Designed Phosphine–Urea Ligand for Highly Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Methacrylonitrile: A Combined Experimental and Theoretical Study”. J. Am. Chem. Soc. 2019141, 961.

(10) Chen, H.; Zhang, T.; Shan, C.; Liu, S.; Song, Q.*; Bai, R.*; Lan, Y.* “Mechanism of Brønsted-Base-Mediated Borylation of Propynols: A DFT Study”. Org. Lett. 201921, 4924.